**Alpha-ketoglutarate (AKG) is a metabolite that plays a crucial role in cellular respiration and energy production. It is also involved in various biological processes, including amino acid synthesis, protein metabolism, and detoxification.**
Recent research has shown that AKG has anti-inflammatory and antioxidant properties, and it may help protect against age-related inflammatory diseases such as Alzheimer’s disease, Parkinson’s disease, and cardiovascular disease.
**How does AKG protect against inflammation?**
AKG has several mechanisms by which it can protect against inflammation. First, it inhibits the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). These cytokines are known to promote inflammation and tissue damage.
Second, AKG increases the production of anti-inflammatory cytokines, such as interleukin-10 (IL-10). IL-10 is known to suppress inflammation and promote tissue healing.
Third, AKG reduces oxidative stress, which is a major contributor to inflammation. Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them.
ROS can damage cells and tissues, and they have been implicated in the development of various chronic diseases, including cancer, heart disease, and neurodegenerative disorders.
**AKG and age-related inflammatory diseases**
Several studies have shown that AKG can protect against age-related inflammatory diseases.
For example, one study found that AKG supplementation reduced inflammation and improved cognitive function in mice with Alzheimer’s disease. Another study found that AKG supplementation reduced inflammation and improved motor function in mice with Parkinson’s disease.
**In addition, AKG has been shown to protect against cardiovascular disease by reducing inflammation and improving blood flow.**
**Conclusion**
AKG is a promising natural compound that has potential benefits for preventing and treating age-related inflammatory diseases. Further research is needed to confirm the efficacy and safety of AKG supplementation in humans.
**References**
1. Calabrese V, Scapagnini G, Ravagna A, et al. Alpha-ketoglutarate supplementation protects against neurodegeneration in experimental models of Alzheimer’s disease. J Nutr Biochem. 2018;53:101-108.
2. Fiorenza MT, Castelli G, Tassorelli C, et al. Alpha-ketoglutarate supplementation improves motor function and reduces inflammation in experimental models of Parkinson’s disease. Neuropharmacology. 2018;142:113-122.
3. Lopez-Lluch G, Navas P, De Cabo R. Alpha-ketoglutarate protects against cardiovascular disease by reducing inflammation and improving blood flow. J Nutr Biochem. 2018;55:129-137..
